Morotti et al. Human Atrial Model 2016  (Markov INa formulation)

Morotti et al. integrated a Na current Markov model (Grandi et al. Biophys J. 2007;93:3835-47, and Wagner et al. Circ Arrhythm Electrophysiol. 2009;2:285-94) into the framework of the Grandi-Bers human atrial model (Circ Res. 2011;109:1055-66, available for download on this website). The Na current model was extended to reproduce the dose-dependent effect of the Na channel blocker ranolazine (as in Moreno et al. Circ Res. 2013;113:e50-61). Matlab code.

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Morotti and Grandi code for logistic regression analysis of populations of electrophysiological models 2017

This package contains the Matlab code used to investigate proarrythmic mechanisms on a population of electrophysiological models with the method of multivariable logistic regression. In this example, the Morotti et al. model of human atrial myocyte (J Mol Cell Cardiol. 2016 Jul;96:63-71, available for download on this website) is used to create a family of 1000 model variants by perturbing model parameters, and to simulate an electrophysiological protocol that enhances EAD proclivity. Logistic regression analysis allows relating changes in model parameters to the presence/absence of EADs.

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Ellinwood et al. Human Atrial Model 2017 (new Markov-type IKur model)

Ellinwood et al. integrated a Markov-type model of the IKur current derived from Zhou et al. (PLoS ONE 2012; e42295), modified to fit voltage-clamp data from human atrial myocytes, into the Morotti et al. human atrial model (J Mol Cell Cardiol. 2016 Jul; 96:63-71, available for download on this webpage). The IKur current model was extended to reproduce dose-dependent drug binding to various conformational states of the channel with variable affinity and binding kinetics. Matlab code

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Morotti et al. Mouse Sinoatrial Myocyte Model 2021 Matlab code

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Ni et al. Synergy Multi-K channel block in Human Atrial Models 2021 C++ code

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Zhang et al. TATS system in Human Atrial Myocytes C++ code

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