Morotti et al. Cross-species Translators of Electrophysiological Response 2021
The Matlab code of the updated human, rabbit, and mouse biophysical model and the regression-based translators are available for download here.
Grandi-Pasqualini-Bers Human Ventricular Model 2010
The Grandi-Pasqualini-Bers Model was developed within the framework of the Shannon-Bers rabbit ventricular model and based on experimental data obtained in human ventricular myocytes.The Matlab code of the model is available for download here.
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Fogli Iseppe et al. Male and Female Human Epicardial Ventricular Myocyte Models 2021 Code is available here.
Morotti-Grandi-Bers Rabbit Ventricular Model 2012
The Morotti-Grandi-Bers model was developed integrating a modified version of the L-type Ca current (LTCC) model by Mahajan et al. (Biophys J. 2008 Jan 15;94(2):392-410) into the framework of the Shannon-Bers rabbit ventricular model (available for download on this website). The LTCC model was extended to reflect more faithfully contributions of CDI and VDI to total inactivation. Simulink code and Matlab code.
Negroni et al. Rabbit Ventricular Model with Myofilament Contraction 2015
The Negroni et al. model describes excitation-contraction coupling in the rabbit ventricular myocytes. A new model of myofilament contraction is here included into an established (and updated) computational framework, which integrates descriptions of electrophysiology, Ca and Na handling (from Shannon et al. Biophys J. 2004 Nov;87(5):3351-71), Ca/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) signaling pathways (from Soltis and Saucerman, Biophys J. 2010 Oct 6;99(7):2038-47). Matlab code.
Model of IKs Ca- and PKA-dependence in Rabbit Ventricular Myocytes 2017
The model was developed modifying the formulation of the delayed rectifier K current IKs in the parent model developed by Negroni et et al. (J Mol Cell Cardiol. 2015 Apr;81:162-75, available for download on this website). The new formulation reproduces the experimentally observed Ca- and PKA-dependent regulation of IKs. The Matlab code of the full myocyte model is availble for download here.
Morotti et al. Mouse Ventricular Model 2014
The Morotti et al. model describes excitation-contraction coupling in the mouse ventricular myocyte with integrated descriptions of Ca, Ca/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A signaling pathways. This model was built upon the Soltis and Saucerman rabbit ventricular model (Biophys J. 2010 Oct 6;99(7):2038-47) and incorporates the experimentally known differences in mouse vs. rabbit electrophysiology, Ca handling, and kinase signaling and target phosphorylation. Model parameters were also tuned to recapitulate the electrophysiologic changes during chronic (transgenic) CaMKII overexpression. Matlab code.
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Mouse Ventricular Model with Myofilament Contraction
The Morotti et al. model of mouse ventricular myocyte (J Physiol. 2014 Mar 15;592(6):1181-97, available for download on this website) is here modified to integrate the Negroni et al. model of myofilament contraction (J Mol Cell Cardiol. 2015 Apr;81:162-75, see rabbit model available for download on this website). This model was developed to investigate the compartmentalization of cAMP/PKA signaling in Surdo et al. Nat Commun. 2017. Matlab code here.
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