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  1. Peters C, Rickert C, Morotti S, Grandi E, K. Aronow, K. Beam, Proenza C. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. BIORXIV/2022/490938 JGP in press

  2. Zhang X, Ni H, Morotti S, Smith C, Sato D, Louch WE, Edwards AG, Grandi E. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. BIORXIV/2022/500273 J Physiol 2022

  3. Zhang X, Smith C, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+-handling protein variation. BIORXIV/2022/500278 J Physiol 2022

  4. A. Saljic, E. Grandi, D. Dobrev. TGF-β1-induced endothelial-to-mesenchymal transition: a novel potential contributor to atrial fibrillation promoting fibrotic remodeling? JCI. In press

  5. S. Morotti, C. Liu, B. Hegyi, H. Ni, A. Fogli Iseppe, L. Wang, M. Pritoni, C.M. Ripplinger, D.M. Bers, A.G. Edwards, E. Grandi. Quantitative cross-species translators of cardiac myocyte electrophysiology: model training, experimental validation, and applications. Sci Adv. 2021 Nov 19;7(47):eabg0927. 

  6. S. Morotti, H. Ni, C.H. Peters, C. Rickert, A. Asgari Targhi, D. Sato, A.V. Glukhov, C. Proenza, E. Grandi@. Intracellular Na+ modulates pacemaking activity in murine sinoatrial node myocytes: an in silico analysis. Int J Mol Sci, 22 (11), 5645.

  7. C. Peters, E. Sharpe, S. Gantz, S. Morotti, E. Grandi, B.P. Bean, C. Proenza. Ohmic voltage dependence and bi-direction flow of the funny current (If) during the cardiac cycle in murine sinoatrial myocytes. Proc Natl Acad Sci U S A. 118 (28) e2104668118.

  8. A. Fogli Iseppe, H. Ni, X. Zhang, PC Yang, U. Srivatsa, C.E. Clancy, A. G. Edwards, S. Morotti, E. Grandi@. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 Aug;110(2):380-391.

  9. A.D. McCulloch, E. Grandi, J. Saucerman. Computational Models of Cardiovascular Regulatory Mechanisms. J Mol Cell Cardiol. 2021 Jun;155:111.

  10. H. Ni, A. Fogli-Iseppe, W.R. Giles, S.M. Narayan, H. Zhang, A.G. Edwards, S. Morotti, E. Grandi@. Populations of in silico myocytes and tissues reveal synergy of multi-atrial-specific K+ current block in atrial fibrillation. Br J Pharmacol 2020 Jul 15;177(19):4497-515.

  11. A. Zaza@ and E. Grandi@. Mechanisms of Cav3-associated arrhythmia: Protein or microdomain dysfunction? Int J Cardiol. 2020 Dec 1;320:97-99.

  12. B. Xu, M. Li, Y. Wang, M. Zhao, S. Morotti, Q. Shi, Q. Wang, F. Barbagallo, J.P.Teoh, G.R. Reddy, E. Bayne, Y. Liu, A. Shen, J.L. Puglisi, Y. Ge, J. Li, E. Grandi, M. Nieves-Cintron, and Y.K. Xiang. GRK5 controls SAP97-dependent cardiotoxic beta1 adrenergic receptor-CaMKII signaling in heart failure, Circ Res. 2020 Aug 28;127(6):796-810.

  13. K. Tazmini, M. Frisk, A. Lewalle, S. Morotti, D.B. Lipsett, O Manfra, J. Skogested, J.M. Aronsen, O.M. Sejersted, I. Sjaastad, A.G. Edwards, E. Grandi, S.A. Niederer, E. Øie, and W.E. Louch. Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circ Res. 2020 Mar 27;126(7):889-906.

  14. E. Grandi@ and D. Dobrev@. Atrial fibrillation in a dish: Insights into atrial arrhythmogenesis from induced pluripotent stem cell derived cardiomyocytes. Cardiovasc Res. 2020 May 1;116(6):1089-1091. Editorial

  15. Z. Li, G. Mirams, T. Yoshinaga, B. Ridder, X. Han, J. Chen, N. Stockbridge, T. Wisialowski, B. Damiano, S. Severi, P. Morissette, P. Kowey, M. Holbrook, G. Smith, R. Rusmusson, M. Liu, Z. Song, Z. Qu, D. Leishman, J. Steidl-Nichols, B. Rodriguez, A. Bueno-Orovio, X. Zhou, E. Passini, A. Edwards, S. Morotti, H. Ni, E. Grandi, C. Clancy, J. Vandenberg, A. Hill, M. Nakamura, T. Singer, L. Polonchuk, A. Greiter-Wilke, K. Wang, S. Nave, A. Fullerton, E. Sobie, M. Paci, F. Musuamba Tshinanu, D. Strauss. General Principles for the Validation of Proarrhythmia Risk Prediction Models: an Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther, 2020 Jan;107(1):102-111.

  16. D.C. Kernik, S. Morotti, H.J. Duff, J. Kurokawa, J. Jalife, J.C. Wu, E. Grandi@, C.E. Clancy@. A Computational Analysis of Inter-subject Variability in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J Physiol. 2019 Sep;597(17):4533-4564. Top 10% most downloaded articles in the 12 months after publication

  17. L. Wang, S. Morotti, S. Tapa, S.D. Francis Stuart, Y. Jiang, R.C. Myles, Ng, D.M. Bers, E. Grandi, C.M. Ripplinger. Different paths, same destination: Divergent electrophysiological responses result in conserved cardiac fight or flight response in mouse and rabbit hearts. J Physiol. 2019 Aug;597(15):3867-3883. 

  18. E. Grandi@ and C.M. Ripplinger. Antiarrhythmic mechanisms of beta blocker therapy. Pharmacol Res. 2019 Aug;146:104274. Review.

  19. A.U. Syed, G.R. Reddy, D. Ghosh, M.P. Prada, M.A. Nystoriak, S. Morotti, E. Grandi, P. Sirish, N. Chiamvimonvat, J.W. Hell, L.F. Santana, Y.K. Xiang, M. Nieves-Cintrón and M.F. Navedo. AC5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 Jun 4;129(8):3140-3152. Recommended by [Faculty of 1000] https://f1000.com/prime/735907400

  20. B. Hegyi, S. Morotti, C. Liu, T. Bányász, K.S. Ginsburg, J. Bossuyt, L. Belardinelli, L.T. Izu, Y. Chen-Izu, E. Grandi, D.M. Bers. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-dependent and β‑Adrenergic Effects on Late Sodium, L-type Calcium and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 Mar;12(3):e007061. 

  21. E. Grandi, D. Dobrev, J. Heijman. Computational modeling: what does it tell us about atrial fibrillation mechanisms and therapy? Int J Cardiol. 2019 Jul 15;287:155-161. 

  22. H. Ni, H. Zhang, E. Grandi, S. Narayan, W. Giles. Transient Outward K Current Can Strongly Modulate Action Potential Duration and Initiate Alternans in Human Atrium. Am J Physiol Heart Circ Physiol. 2018 Jul 20;9:958.

  23. H. Ni, S. Morotti, E. Grandi@. A heart for diversity: simulating variability in cardiac arrhythmia research. Front Physiol. 9:958. Review

  24. Morotti, E. Grandi@. Quantitative systems models illuminate arrhythmia mechanisms in heart failure: role of the Na-Ca-CaMKII-ROS feedback. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul 17:e1434. Review

  25. E. Grandi@, S. Morotti, E. Pueyo, B. Rodriguez. Getting to the heart of safety Pharmacology. Front Physiol. 2018 Jun 8 9:678. Editorial

  26. E. Grandi@. Keeping it short and (not so) simple: Characterizing hERG kinetics with sinusoidal waves. J Physiol. 2018 May 15;596(10):1783-1784

  27. E. Grandi@ and D. Dobrev@. Non-ion channel therapeutics for heart failure and atrial fibrillation: are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol 2018 Aug;121:300-303. Editorial

  28. F.A. Ortega, E. Grandi, T. Krogh-Madsen, D. Christini. Novel applications of dynamic clamp to cardiac arrhythmia research: Role in drug target discovery and safety pharmacology testing. Front Physiol. 2018 Jan 4;8:1099.

  29. R. Vaidyanathan, H. Van Ert, K.T. Haq, S. Morotti, E. McCune, S. Esch, J. Warden, S. Abozeid, E. Grandi, L. Eckhardt. Caveolin-3 and Kir2.x Domain-Specific Interaction and Related Purkinje-Dependent Arrhythmia Mechanism. Circ Arrhythm Electrophysiol. 2018 Jan;11(1):e005800. 

  30. N. Ellinwood, D. Dobrev, S. Morotti, E Grandi. In silico assessment of efficacy and safety of IKur inhibitors in chronic atrial fibrillation: role of kinetics and state-dependence of drug binding. Front Pharmacol. 2017 Nov 7;8:799.

  31. N. Ellinwood, D. Dobrev, S. Morotti, E. Grandi@. Effects of kinetics and state dependent binding properties of IKur-targeting drugs on atrial electrophysiology. Chaos. 2017 27, 093918.

  32. S. Morotti, M. Nieves-Cintrón, M.A. Nystoriak, M.F. Navedo§@, E. Grandi§@. Hyperglycemia-induced L-type Ca channel stimulation outweighs K channel suppression to impair intracellular calcium and vascular reactivity of cerebral arteries. Channels (Austin). 2017 Jul 4;11(4):340-346.

  33. N.C. Surdo, M. Berrera, A. Koschinski, M. Brescia, M.R. Machado, C. Carr, Morotti, E. Grandi, P. Wright, D.M. Bers, J. Gorelik, S. Pantano, M. Zaccolo. FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun 2017 Apr 20;8:15031.

  34. M.A. Nystoriak, M. Nieves-Cintrón, T. Patriarchi, S. Morotti, E. Grandi, J. Fernandez Dos Santos, K. Forbush, F. Hofmann, K.C. Sasse, S.M. Ward, J.D. Scott, J.W. Hell, M.F. Navedo. CaV1.2 Ser1928 phosphorylation by PKA stimulates L-type Ca2+ channels and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling, 10 eaaf9647. Featured in Science Signaling Podcast. Journal Issue Cover.

  35. D.C. Bartos, S. Morotti, K.S. Ginsburg, E. Grandi and D.M. Bers. Ca2+-dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 Apr 1;595(7):2253-2268. Highlighted by editorial.

  36. E. Grandi@,&. Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in cardiac action potential stability. J Physiol. 2017 Apr 1;595(7):2319-2320. Editorial.

  37. E. Grandi@, M.C. Sanguinetti, D.C. Bartos, D.M. Bers, Y. Chen-Izu, N. Chiamvimonvat, H. Colecraft, B.P. Delisle, J. Heijman, M.F. Navedo, S. Noskov, C. Proenza, J.I. Vandenberg, V. Yarov-Yarovoy. Potassium channels in the heart: Structure, function and regulation. J Physiol, Special Issue on K Channels and Cardiac Electrophysiology. J Physiol. 2017 Apr 1;595(7):2209-2228. White paper. Journal Issue Cover.

  38. N. Chiamvimonvat, Y. Chen-Izu, C.E. Clancy, I. Deschenes, D. Dobrev, J. Heijman, L. Izu, Z. Qu, C.M. Ripplinger, J.I. Vandenberg, J. Weiss, G. Koren, E. Grandi, M.C. Sanguinetti, D. M. Bers, J. Nerbonne. Functional roles of cardiac K channels in normal and diseased heart. J Physiol, Special Issue on K Channels and Cardiac Electrophysiology. J Physiol. 2017 Apr 1;595(7):2229-2252. White paper.

  39. S. Morotti and E. Grandi@. Logistic regression analysis of population of electrophysiological models to assess proarrythmic risk. MethodsX. 2017;4:25-34.

  40. E. Grandi@,& and M.M. Maleckar. Computational modeling aids discovery, development, and optimization of anti-arrhythmic strategies for atrial fibrillation. Pharmacol Ther. 2016 Dec;168:126-142. Review.

  41. S. Morotti, A.D. McCulloch, D.M. Bers, A.G. Edwards, E. Grandi@. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016; 96:63-71.

  42. P-C. Yang*, J.D. Moreno*, C.Y. Miyake, S.B. Vaughn-Behrens, M-T Jeng, E. Grandi, X.H.T. Wehrens, S. Noskov, C.E. Clancy. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. JPhysiol. 2016; 594(3):567-93.

  43. Y. Xie, Z. Liao, E. Grandi, Y. Shiferaw, D.M. Bers. Slow [Na]i changes and positive feedback between membrane potential and [Ca]i underlie intermittent early afterdepolarizations and arrhythmias. Circ Arrhythm Electrophysiol. 2015; 8(6):1472-1480.

  44. D.C. Bartos*, E. Grandi*, C.M. Ripplinger. Ion Channels in the Heart. Comprehensive Physiology Compr Physiol 2015 Jul; 5:1423-1464. Review&.

  45. Y. Chen-Izu, R. Shaw, G. Pitt, V. Yarov-Yarovoy, J. Sack, V. Maltsev, I. Deschenes, P. Mohler, H. Abriel, R. Aldrich, M. Cannell, W. Chazin, N. Chiamvimonvat, E. Grandi, T. Hund, L.T. Izu, L.S. Maier, C. Marionneau, R. Rasmussen, E.A. Sobie, C.E. Clancy, D.M. Bers. Na Channel Function, Regulation, Structure, Trafficking and Sequestration. J Physiol. 2015 Mar 15;593(6):1347-60.

  46. J.A. Negroni, S. Morotti, E.C. Lascano, A.V. Gomes, E. Grandi, J.L. Puglisi, D.M. Bers. Modeling beta-adrenergic effects on cardiac contraction-relaxation in an integrated rabbit ventricular myocytes model. J Mol Cell Cardiol. 2015 Feb 25;81:162-175.

  47. A.G. Edwards, E. Grandi, J.E. Hake, S. Patel, P. Li, B.D. Westenbrink, J. H. Omens, J.H. Brown, D.M. Bers, A.D. McCulloch. Non-equilibrium reactivation of the Na current drives early afterdepolarizations in the mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1205-13.

  48. E. Grandi@, A.G. Edwards, A.W. Herren, D.M. Bers. CaMKII comes of age in cardiac health and disease. Front Pharmacol, 2014 Jul 3;5:154. Editorial&.

  49. E. Grandi@ and A.W. Herren. CaMKII-dependent regulation of cardiac Na homeostasis. Front Pharmacol. 2014 Mar 10;5:41. Review&.

  50. S. Morotti, A.G. Edwards, A.D. McCulloch, D.M. Bers E. Grandi@. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na loading and CaMKII. J Physiol. 2014 Mar 15;592(Pt 6):1181-97.

  51. Y. Xie, E. Grandi, D.M. Bers, D. Sato. Protocol dependence of action potential wave dynamics in cardiac tissue. Europace 2014 Mar;16(3):452-7.

  52. J.D. Moreno*, P-C. Yang*, J.R. Bankston, E. Grandi, D.M. Bers, R.S. Kass, C.E. Clancy. Ranolazine for congenital and acquired late INa linked arrhythmias: in silico pharmacologic screening. Circ Res. 2013 Sep 13;113(7):e50-61.

  53. A.W. Herren, D.M. Bers, E. Grandi@. Post-translational Modifications of the Cardiac Na Channel. Contribution of CaMKII-Dependent Phosphorylation to Acquired Arrhythmias. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H431-45. Review&.

  54. Y. Xie, E. Grandi, Puglisi J., D. Sato, D.M. Bers. β-Adrenergic Stimulation Activates Early Afterdepolarizations Transiently via Kinetic Mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61.

  55. S. Morotti*, E. Grandi*, A. Summa, K.S. Ginsburg, D.M. Bers. Theoretical Study of L-type Ca Current Inactivation Kinetics during Action Potential Repolarization and Early Afterdepolarizations. J Physiol. 2012 Sep 15;590(Pt 18):4465-81.

  56. E. Grandi, A.J. Workman, and S.V. Pandit. Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation. JAFIB, 2012 Apr;2(10). Review&.

  57. D.M. Bers and E. Grandi. Human Atrial Fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med., 2011 Jul;21(5):145-150. Review&.

  58. E. Grandi*, S.V. Pandit*, N. Voigt*, A.J. Workman, D. Dobrev, J. Jalife§, and D.M. Bers§. Human Atrial Action Potential and Ca Model: Sinus Rhythm and Chronic Atrial Fibrillation. Circ Res, 2011; 109:1055-66. Highlighted in the Circulation Research thematic synopsis on cardiac arrhythmias in the top 10 downloaded articles (Circ Res. 2012;111:e178-e202).

  59. L. Wu, J. Ma, H. Li, C. Wang, E. Grandi, P. Zhang, A. Luo, D.M. Bers, J.C. Shryock, L. Belardinelli. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation, 2011 Apr 26;123(16):1713-20.

  60. S. Wagner, H.M. Ruff, S.L. Weber, S. Bellmann, T. Sowa, T. Schulte, E. Grandi, D.M. Bers, J. Backs, L. Belardinelli, and L. S. Maier. ROS-activated Ca/calmodulin kinase IIδ is required for late INa augmentation leading to cellular Na and Ca overload. Circ Res, 2011 Mar 4;108(5):555-65.

  61. E. Grandi, S. Morotti, K.S. Ginsburg, S. Severi, D.M. Bers. Interplay of Voltage and Ca-dependent Inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep;103(1):44-50.

  62. E. Grandi, F.S. Pasqualini, D.M. Bers. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan;48(1):112-21. Recommended by [Faculty of 1000] http://f1000.com/13121964.

  63. D.M. Bers and E. Grandi. CaMKII Regulation of Cardiac Ion Channels. J Cardiovasc Pharmacol. 2009 Sep; 54(3):180-187. Review&.

  64. S. Wagner, E. Hacker, E. Grandi, S.L. Weber, N. Dybkova, S. Sossalla, T. Sowa, L. Fabritz, P. Kirchhof, D.M. Bers, L.S. Maier. Ca/Calmodulin Kinase II Differentially Modulates Potassium Currents. Circ Arrhythm Electrophysiol. 2009 Jun;2(3):285-94.

  65. E. Grandi, F.S. Pasqualini, C. Pes, C. Corsi, A. Zaza, S. Severi. Theoretical investigation of action potential duration dependence on extracellular Ca in human ventricular myocytes. J Mol Cell Cardiol. 2009 Mar;46(3):332-42.

  66. E. Grandi*, M. Govoni*, S. Furini*, S. Severi, E. Giordano, A. Santoro, S. Cavalcanti. Induction of NO synthase 2 in ventricular cardiomyocytes incubated with conventional bicarbonate dialysis bath. Nephrol Dial Transplant. 2008 Jul;23(7):2192-7.

  67. A. Santoro, E. Mancini, G. London, L. Mercadal, H. Fessy, B. Perrone, L. Cagnoli, E. Grandi, Severi S., Cavalcanti S. Patients with Complex Arrhythmias During and after Haemodialysis Suffer from Different Regimens of Potassium Removal. Nephrol Dial Transplant. 2008 Apr; 23(4):1415-21.

  68. S. Severi*, E. Grandi*, C. Pes, F. Badiali, F. Grandi, A. Santoro. Calcium and Potassium Changes During Haemodialysis alter Ventricular Repolarization Duration: in vivo and in Silico Analysis. Nephrol Dial Transplant. 2008 Apr;23(4):1378-86.

  69. E. Grandi, J.L. Puglisi, S. Wagner, L.S. Maier, S. Severi, D.M. Bers. Simulation of Ca-Calmodulin-Dependent Protein Kinase II on Rabbit Ventricular Myocyte Ion Currents and Action Potentials. Biophys J. 2007 Dec 1; 93(11):3835-47.

  70. S. Vecchietti, E. Grandi, S. Severi, I. Rivolta, C. Napolitano, S.G. Priori, S. Cavalcanti. In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H56-65.

  71. S. Severi, A. Ciandrini, E. Grandi, S. Cavalcanti, S. Bini, F. Badiali, A. Gattiani, L. Cagnoli. Cardiac response to hemodialysis with different cardiovascular tolerance: heart rate variability and QT interval analysis. Hemodial Int. 2006 Jul; 10(3):287-93.

 

*equal contribution, §shared senior author, @corresponding author, &invited

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